口腔微生物群和致癌性:探索口腔病原体的系统影响
Nađa Nikolić1, Ana Pucar1, Uroš Tomić1
1School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Pathogens (Basel, Switzerland)
|December 31, 2025
概括
口腔微生物群,特别是某些细菌,如 Porphyromonas gingivalis,与口腔以外的各种癌症有关. 这种失生症有助于炎症,遗传毒性和免疫抑制,为癌症检测和治疗提供了新的途径.
科学领域:
- 微生物组研究的研究.
- 在瘤学瘤学.
- 系统性疾病机制 系统性疾病机制
背景情况:
- 传统上,癌症风险主要集中在局部因素上.
- 新出现的证据表明,口腔微生物组与系统性瘤发生有关.
- 口腔失生症越来越被认为是非口腔恶性瘤的一个因素.
研究的目的:
- 审查临床和机械学数据,将口腔失生症与全身癌症联系起来.
- 总结口腔细菌在各种恶性瘤中的器官特异性关联.
- 探索口腔细菌在癌症发展中的潜在机制和传播途径.
主要方法:
- 临床和机械学研究的综合.
- 从唾液,组织和便样本中分析特定器官的关联.
- 对分子机制的审查,包括炎症,基因毒性,免疫逃避和表观遗传变化.
主要成果:
- 口腔细菌,包括 Porphyromonas gingivalis,Fusobacterium nucleatum和Treponema denticola,在各种癌症 (胃肠道,呼吸道,乳腺等) 中得到丰富. ) 的情况.
- 机制包括持续的炎症,直接的基因毒性,免疫抑制和表观遗传改变.
- 可能的传播途径包括口腔-肠-全身轴,血液,淋巴和微吸.
结论:
- 口腔失生症是瘤发生的一个临床相关的辅因子.
- 基于生物标志物的风险分层和使用唾液/便试验的早期检测的潜力.
- 针对微生物组的干预措施可以补充传统的癌症控制策略.
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