对土耳其马的非灵长类肝炎病毒感染的风险决定因素和分子特征的评估
Mustafa Ozan Atasoy1, Turhan Turan1, Remziye Özbek1
1Department of Veterinary Virology, Faculty of Veterinary Medicine, Cumhuriyet University, 58140 Sivas, Türkiye.
Pathogens (Basel, Switzerland)
|December 31, 2025
概括
非灵长类肝炎病毒 (NPHV) 感染在马中很常见,年龄和位置是关键的风险因素. 这项研究分析了土耳其的NPHV流行率和分子特征,为预防提供了洞察力.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子流行病学分子流行病学
- 传染性疾病 传染性疾病
背景情况:
- 非灵长类肝炎病毒 (NPHV) 在包括马在内的各种动物物种中越来越多地被识别出来.
- 之前对马类NPHV的研究已经给出了关于感染风险因素的不确定的结果.
- 了解NPHV流行病学对于管理马类慢性感染至关重要.
研究的目的:
- 调查土耳其不同地理位置的马匹中NPHV感染的流行率和分子特征.
- 确定与NPHV感染相关的潜在风险因素,如年龄,品种和性别.
- 分析新型NPHV菌株的遗传多样性.
主要方法:
- 传统的PCR针对152个来自土耳其十个城市的马匹样本的NPHV5' UTR.
- 阳性样本的5'UTR,NS3和NS5B区域的测序.
- 遗传学分析和病毒基因组序列的in silico 3D建模.
- 统计分析将感染率与地理数据,马群统计和管理实践相关联.
主要成果:
- 在研究的马群中检测到总体高达52.3%的NPHV感染率.
- 不同城市的感染率差异很大,从26.1%到75.0%不等.
- 年龄,地理区域和管理因素被确定为NPHV感染的重要决定因素.
结论:
- 这项研究提供了关于土耳其马的NPHV分布和流行率的关键数据.
- 识别的风险因素,如年龄和位置,可以为有针对性的监测和预防策略提供信息.
- 新型NPHV菌株的表征有助于更好地了解病毒演变和诊断.
相关概念视频
01:27Myocarditis II: Clinical Features and Diagnostic Tests
493
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
493
01:25Arboviral Encephalitis
59
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
59
01:25Hepatitis
86
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
86