潘特拉辛3水平反映了人类内脏莱什曼病的炎症和寄生活动
Lucyo Flávio Bezerra Diniz1,2,3, Milena Xavier Silva Barbosa4,5, Samuel Ricarte de Aquino2,6
1Postgraduate Program in Health and Biological Sciences, Federal University of the São Francisco Valley (UNIVASF), Petrolina 56304-917, Pernambuco, Brazil.
Pathogens (Basel, Switzerland)
|December 31, 2025
概括
在内脏莱什曼病 (VL) 患者中,潘特拉辛3 (PTX3) 水平升高,与寄生虫负载和炎症相关. PTX3可以作为一种有价值的疾病活动指标在VL.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 寄生虫学的寄生虫学
背景情况:
- 内脏莱什曼病 (VL) 是一种严重的,致命的动物性疾病,具有显著的炎症成分.
- 反映VL炎症和寄生活动的宿主衍生生物标志物有限.
- 潘特拉辛3 (PTX3) 在人体VL病变发生过程中的作用尚不清楚.
研究的目的:
- 在VL患者中调查血PTX3水平,寄生虫负担和PTX3基因多态性之间的关联.
- 为了评估PTX3作为潜在的生物标志物在内脏莱什曼病的疾病活动.
主要方法:
- 观察性研究 (2017-2021年) 与36名VL患者和45名健康对照进行.
- 用ELISA测量的血PTX3度.
- 用qPCR量化的寄生虫负载;通过流细胞计评估的细胞因子水平.
主要成果:
- 与对照组相比,VL患者的血PTX3水平显著更高 (23.2 ng/mL与0.80 ng/mL相比;p < 0.0001).
- PTX3水平与寄生虫负荷 (r = 0.39; p = 0.02) 和特定细胞因子 (IL-6,IL-10,IFN-γ) 有正相关.
- 没有发现PTX3基因多态 (rs1840680,rs2305619) 和VL敏感性之间的关联.
结论:
- 血水平的PTX3反映了炎症反应和寄生虫负担在内脏莱什曼病.
- PTX3显示出作为监测VL疾病活动的宿主衍生生物标志物的潜力.
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