一种基于FAPI的新型放射性药物用于纤维化间歇性肺部疾病的SPECT成像
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Guangjie Yang1, Jingnan Wang1, Yu Liu1
1Department of Nuclear Medicine, State Key Laboratory of Complex, Severe, and Rare Diseases, Center for Rare Diseases Research, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.
Pharmaceuticals (Basel, Switzerland)
|December 31, 2025
概括
这项研究引入了一种新的放射性药物99mTc-H-PoFP2,用于检测纤维化间歇性肺病 (fILD) 的SPECT成像. 该药物向纤维细胞激活蛋白 (FAP),显示出对非侵入性肺纤维化评估的前景.
科学领域:
- 核医学是一种核医学.
- 放射性药物开发 放射性药物开发
- 肺部医学 肺部医学
背景情况:
- 早期发现纤维化间歇性肺病 (fILD) 是至关重要的,但具有挑战性.
- 目前肺纤维化诊断方法缺乏非侵入性和精确的评估能力.
研究的目的:
- 评估99mTc-HYNIC-Glu(PEG4-oncoFAPi) 2 (99mTc-H-PoFP2) 的可行性,用于肺纤维化的SPECT成像.
- 在小鼠模型和针对纤维细胞激活蛋白 (FAP) 的初步人类研究中评估99mTc-H-PoFP2的诊断潜力.
主要方法:
- 开发和验证99mTc-H-PoFP2,一种针对FAP的新型99mTc标记放射性药物.
- 在体外结合测定以确认FAP的特异性和亲和力.
- 在活体SPECT/CT成像中,用白素诱导的肺纤维化小鼠模型和12名fILD患者进行成像.
主要成果:
- 99mTc-H-PoFP2 呈现出快速的尿排泄,正常组织吸收率低,目标与背景比率高.
- 在小鼠模型和fILD患者中,SPECT成像显示纤维化肺组织的吸收显著增加.
- 肺吸收与肺功能测试和GAP指数相关,表明疾病严重程度.
结论:
- 99mTc-H-PoFP2是一种有前途的放射性药物,用于野外的SPECT成像.
- 用99mTc-H-PoFP2针对FAP提供了一种新的,非侵入性的方法来评估肺纤维化.
- 这一策略提高了fILD诊断和监测的精度和非侵入性.
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