白河迪黄唐通过调节MAOA介导的血清素代谢和突触可塑性发挥抗抑郁作用
Defu Tie1,2, Yuting Wang2, Jieru Zhou2
1College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Pharmaceuticals (Basel, Switzerland)
|December 31, 2025
概括
白河迪黄唐 (BDT) 通过调节血清素代谢和增强突触可塑性来缓解抑郁症. 这种传统的草药配方抑制了MAOA的活动,增加了血清激素水平并改善了与情绪相关的行为.
科学领域:
- 综合医学是一个整体的医学.
- 神经药理学神经药理学
- 传统中国医药 传统中国医药
背景情况:
- 白河 (Baihe Dihuang Tang,简称BDT) 是一种用于治疗抑郁症的古典草药配方.
- 它用于治疗抑郁症的精确药理机制尚未完全理解.
- 研究BDT对血清代谢和突触可塑性的影响至关重要.
研究的目的:
- 通过检查其对MAOA调节的血清素 (5-HT) 代谢和突触可塑性的影响,探索BDT的抗抑郁作用.
- 通过网络药理学识别BDT的潜在MAOA向活性成分.
- 为预测的机制提供实验验证.
主要方法:
- 使用TCMSP和TCMID数据库选BDT活动组件和目标.
- 构建了一个组件-目标-路径网络.
- 建立了抑郁症的慢性克制压力 (CRS) 诱导的小鼠模型.
- 进行行为测试 (OFT,EPM,FST,TST) 和分子分析 (ELISA,qRT-PCR,Western blot) 以评估5-HT代谢,BDNF/TrkB信号传递和突触可塑性蛋白.
主要成果:
- 在FST/TST中,BDT显著减少了不运动时间,并改善了类似焦虑的行为.
- BDT降低了MAOA的表达,并增加了海马5-HT/5-HIAA比率.
- BDT激活了BDNF/TrkB通路,并上调了突触可塑性蛋白 (PSD-95,SYN1).
- 网络药理学将MAOA确定为关键目标,并确定酸,咖啡酸和其他生物活性成分.
结论:
- 在小鼠模型中,BDT有效地改善了类似抑郁的行为.
- 抗抑郁药的机制涉及抑制MAOA介导的血清代谢,增加5-HT的生物可用性.
- 这导致BDNF / TrkB信号的激活和增强的突触可塑性,验证MAOA作为主要目标.
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