相关实验视频

Updated: Jan 7, 2026

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

口服大麻素治疗急性抽取后疼痛:一项随机试点研究

Ammaar H Abidi¹, Modar Kassan¹, Karen Derefinko²

¹College of Dental Medicine, Lincoln Memorial University, Knoxville, TN 37917, USA.

Pharmaceuticals (Basel, Switzerland)

|December 31, 2025

概括

这项试点研究表明,较高度的大麻 (CBD) 可以有效地管理牙拔牙疼痛,与标准治疗相比. 需要进一步的研究来证实这些关于缓解疼痛的发现.

科学领域:

口腔手术和疼痛管理
大麻素的药理学大麻素的药理学

背景情况:

手术后的疼痛是牙提取后的一个常见问题.
大麻素 (CBD) 是一种非中毒性大麻素,显示出潜在的止痛和抗炎性质.
正在探索CBD作为急性牙痛的辅助疗法.

研究的目的:

评估口服CBD在简单的牙提取后的疼痛管理中的初步疗效和安全性.
为了比较两种CBD度 (17 mg/mL和37 mg/mL) 与安慰剂和标准非阿片类药物治疗 (ibuprofen/acetaminophen).

主要方法:

一项试验性随机试验 (SWAP试验) 用8名成年人在四个手臂 (每只手臂n=2) 中进行:CBD 17 mg/mL,CBD 37 mg/mL,安慰剂或常规治疗 (TAU).
参与者在7天内根据需要接受研究药物.
主要终点:通过72小时的生态瞬间评估 (EMA) 测量疼痛强度.

主要成果:

所有参与者完成了随访,具有高的EMA坚持 (>75%).
由于样本规模较小,结果是描述性的和初步的.
37 mg/mL CBD 组的疼痛评级与 TAU 组相似,而 17 mg/mL CBD 和安慰剂组的疗效有限.

结论:

更高度的CBD (37 mg/mL) 可能提供与标准非阿片类药物治疗用于提取后疼痛相比的止痛作用.
这些发现是探索性的,并表明高度CBD在疼痛管理中的潜在作用.
一个更大的,强大的随机试验是有必要的,以证实这些初步发现.

关键词:

经手术后的急性疼痛.止痛药止痛药止痛药是一种止痛药.大麻二醇 (CBD) 的使用.牙疼痛牙疼痛牙疼痛非阿片类药物治疗.疼痛管理疼痛管理植物大麻素 (phytocannabinoids) 是一种植物性大麻素.试点临床试验试点临床试验拔牙拔牙的方法拔牙拔牙的方法

更多相关视频

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass

Published on: May 27, 2022

Intracranial Pharmacotherapy and Pain Assays in Rodents

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

相关概念视频

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...