大麻素和细胞外囊作为神经精神疾病的潜在生物标志物和治疗点:以假设为导向的审查
Bruno L Marques1,2, Pedro H C Lirio1,2, Maria A Vicente1,2
1Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, 3900, Bandeirantes Avenue, Monte Alegre, Ribeirão Preto 14049-900, SP, Brazil.
Pharmaceuticals (Basel, Switzerland)
|December 31, 2025
概括
内分泌大麻素系统 (ECS) 和细胞外囊泡 (EVs) 可能相互作用,影响神经精神疾病. 这种相互作用可能会导致新的生物标志物和个性化治疗抑郁症和焦虑症等疾病.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经精神疾病对全球健康构成重大挑战,诊断准确性和治疗疗效有限.
- 目前这些疾病的诊断方法主要是临床的,缺乏客观的生物标志物,导致复发率高.
- 内分泌大麻素系统 (ECS) 和细胞外囊泡 (EVs) 越来越多地被认为是它们在大脑功能和疾病中的作用.
研究的目的:
- 对ECS信号传输和EV介导的沟通趋同,影响神经精神疾病中的脆弱性和弹性进行审查.
- 探索ECS-EV轴在神经精神疾病中的生物标志物发现和治疗创新的潜力.
- 在神经精神疾病的背景下,研究大麻素和EV之间的双向关系.
主要方法:
- 采用了叙事审查方法,专注于大麻素和EVs在神经精神疾病中的交叉点.
- 在2025年9月之前,使用PubMed,Scopus和Web of Science数据库进行文献搜索.
- 该审查综合了关于ECS活动和EV生物学之间的相互作用的新兴证据.
主要成果:
- 有证据表明,ECS活动和EV生物学之间存在双向关系.
- 内分类固醇可以被包装成EV用于细胞间信号传输.
- 像THC和CBD这样的植物性大麻素可以调节EV释放及其分子载荷.
结论:
- 提出了一个以假设为导向的框架,用于神经精神障碍中大麻素和EV之间的相互作用.
- 这种框架可能会刺激新的研究方向.
- 这些发现支持开发基于生物标志物指导的,针对神经精神疾病的个性化治疗策略.
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