用油加载的欧林奶油和水膏的风湿学特征
Shorouq Alzahrani1, Jinsong Hao1
1Department of Pharmaceutical & Clinical Sciences, College of Pharmacy & Health Sciences, Campbell University, Buies Creek, NC 27506, USA.
Pharmaceuticals (Basel, Switzerland)
|December 31, 2025
概括
这项研究使用rheological测试确定了Eucerin和Aquaphor药膏的最大油装载能力. 结果表明,虽然油会影响膏的特性,但可以确定其最大负载能力,而不会影响性能.
科学领域:
- 制药科学 制药科学
- 皮肤病学 皮肤病学
- 材料科学 材料科学 材料科学
背景情况:
- 油表现出治疗皮肤疾病的治疗特性.
- 将活性成分纳入现有的膏基,如Eucerin和Aquaphor,在制药配方中很常见.
- 确定最大的药物载荷容量对于保持药膏特性至关重要.
研究的目的:
- 为了确定Eucerin和Aquaphor膏的最大油装载能力.
- 研究不同油度对这些配方的风湿性质的影响.
主要方法:
- 油被纳入Eucerin和Aquaphor的不同度.
- 使用流量和振荡模式评估了风湿性质.
- 进行了爬行和恢复测试,以评估粘弹性特性.
主要成果:
- 添加油影响了粘度,弹性和粘度模块,合规性和应变.
- 尽管发生了变化,但这两种基体的整体质行为仍然与对照基保持一致.
- 风病学测试成功地发现了由油引起的配方特性变化.
结论:
- 风病学测试是确定油在膏配方中的最大载荷能力的有效方法.
- 这种方法确保局部配方保持所需的性能特征.
- 了解风湿学影响是开发稳定有效的油基皮肤产品的关键.
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