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网络药理学分析和实验研究阴仁治疗缺血性中风中神经炎症的实验研究

Minmin Guo¹, Yijie Ma¹, Linlin Wang²

¹Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Pharmaceuticals (Basel, Switzerland)

|December 31, 2025

概括

阴仁是一种传统的中医药,通过减少神经炎症,显示出缺血性中风的治疗潜力. 它的活性化合物有效地向关键的炎症途径,为这种神经损伤提供了有希望的自然治疗方法.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

缺血性中风 (IS) 是一种重要的神经损伤,其中炎症起着关键作用.
阴仁是一种来自传统中医药 (TCM) 的草药,已知具有抗炎性质,但其对IS的疗效尚未确立.

研究的目的:

为了研究阴禅在治疗缺血性中风方面的治疗潜力.
鉴定阴对IS中神经炎症的影响背后的特定活性化合物和分子机制.

主要方法:

使用HPLC和MS来识别Artemisia scoparia提取物 (ASE) 中的活性化合物.
网络药理学和分子对接确定了在IS中的核心目标.
实验验证涉及过渡性中脑动脉阻塞 (tMCAO) 的老鼠模型和用LPS处理的微质细胞.

主要成果:

在ASE中确定了四种关键化合物 (异基酸A,B,C和基酸).
网络药理学预测了198个与IS的交叉目标,其中TNF,STAT3,IL1B,AKT1和SRC是前五名.
在体外和体外模型中,ASE及其活性化合物证明了剂量依赖的炎症因子抑制和神经保护.

结论:

阴表现出显著的抗神经炎症作用,有利于治疗缺血性中风.
阴禅的治疗潜力归因于其成分,这些成分有效地与关键的炎症标相互作用.
这项研究支持仁作为治疗缺血性中风的天然抗炎剂的使用.

关键词:

阿尔特梅西亚野外植物提取物阴 (Yinchen) 是指阴 (Yinchen) 是指阴的意思.缺血性中风中风分子对接的分子对接.网络药理学网络药理学神经炎症是一种神经炎症.

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