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来自GEIS-33协议的局部高度骨肉瘤患者中的预后药物遗传生物标志物作为VEGF信号通路生殖线多态性

Juliana Salazar¹, María J Arranz², Javier Martin-Broto³

¹Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain.

Pharmaceuticals (Basel, Switzerland)

|December 31, 2025

概括

血管内皮生长因子 (VEGF) 途径的遗传变异会影响局部骨髓瘤患者的存活率. 特定的FLT1和KDR基因变异与这些患者的无复发和整体存活率较差有关.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
药物遗传学药物遗传学

背景情况:

血管内皮生长因子 (VEGF) 信号通路对血管生成至关重要,影响瘤进展和局部骨髓瘤的结果.
了解VEGF途径中的遗传倾向可能会为患者的预后和个性化治疗策略提供见解.

研究的目的:

研究VEGF信号通路中的遗传多态性和局部高度骨髓瘤患者的生存结果之间的关联.
确定潜在的遗传生物标志物,用于预测接受化疗的骨肉瘤患者的预后.

主要方法:

在69位局部高度骨髓肉瘤患者的外周血液样本中,对VEGFA,FLT1 (VEGFR1) 和KDR (VEGFR2) 基因的9个变异的基因定型.
对无复发生存率 (RFS) 和总生存率 (OS) 与遗传多态度相关的分析,调整为手术边缘和病理反应等临床共变量.
利用TaqMan Assay技术进行基因型定型和多变量考克斯回归进行统计分析.

主要成果:

在FLT1变异 (rs7993418和rs9582036) 和生存结果之间发现了显著的关联;特定等位基因的携带者 (rs7993418(C和rs9582036(C)) 呈现出更糟糕的RFS和OS.
KDR rs1551641 (TT基因型) 与更糟糕的RFS显著相关.
这些关联在多变量分析后仍然具有统计学意义,表明它们的独立预测值.

结论:

在VEGF途径中的生殖系多态性,特别是FLT1中,可以作为局部高度骨髓瘤患者生存的预测生物标志物.
药物遗传学有可能在骨髓瘤治疗中推进精准医学.
建议在更大的队列中进一步验证,以确认这些遗传标记物的临床实用性.

关键词:

在VEGF中,VEGF是VEGF.骨质肉瘤是骨质肉瘤的一种.药物遗传学药物遗传学多形态主义的多态主义.

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