罗斯瓦斯塔丁与阿托瓦斯塔丁对2型糖尿病患者心血管疾病风险:一项韩国队列研究
Chaeyoon Kim1, Junhyuk Chang2, Sujin Gan2
1Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
Pharmaceuticals (Basel, Switzerland)
|December 31, 2025
概括
罗斯瓦斯塔丁和阿托瓦斯塔丁在2型糖尿病患者中显示出类似的心血管保护和安全性. 使用罗斯瓦斯塔丁的老年人患外周动脉疾病的风险略高,但总的来说,这两种他类药物在治疗上是相当的.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 2型糖尿病 (T2D) 患者需要心血管保护,罗斯瓦斯塔丁和阿托瓦斯塔丁是常见的选择.
- 需要现实世界的数据来比较这些他类药物的临床有效性和安全性,特别是在老年人中.
研究的目的:
- 在T2D患者中比较罗斯瓦斯塔丁与阿托瓦斯塔丁的心血管和安全结果.
- 专门分析老年人 (≥65岁) 的结果.
主要方法:
- 使用来自10家韩国医院的电子健康记录进行的回顾性队列研究.
- 倾向性得分匹配用于比较49 034名T2D患者的结局,这些患者新处方罗苏瓦斯塔丁或阿托瓦斯塔丁.
- 主要结局包括主要的不良心血管事件;二次结局和安全结局也被评估.
主要成果:
- 在所有患者中,罗苏瓦斯塔丁和阿托瓦斯塔丁之间没有观察到心血管或安全结果的显著差异.
- 在65岁以上的患者中,罗斯瓦斯塔丁与周围动脉疾病 (PAD) 的风险略高有关.
结论:
- 罗斯瓦斯塔丁和阿托瓦斯塔丁在T2D患者中表现出可比的心血管有效性和安全性.
- 虽然在老年人中,罗苏瓦斯塔丁的PAD风险略有增加,但差异很小,支持个性化他类药物治疗.
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