Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Cancer Vaccines01:30

Cancer Vaccines

926
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
926
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Normothermic Machine Perfusion vs. Static Cold Storage for DBD Liver Transplantation in High-MELD Recipients: A Single-Center Retrospective Study.

Journal of hepato-biliary-pancreatic sciences·2026
Same author

Normothermic Regional Perfusion in Controlled Donation After Circulatory Death: Growing Evidence for Liver Transplantation.

Clinical transplantation·2026
Same author

Molecular Determinants of Per- and Polyfluoroalkyl Substances Binding to Estrogen Receptors.

Toxics·2025
Same author

Uncovering the Tumorigenic Blueprint of PFOS and PFOA Through Multi-Organ Transcriptomic Analysis of Biomarkers, Mechanisms, and Therapeutic Targets.

Current issues in molecular biology·2025
Same author

PLAIG: Protein-Ligand Binding Affinity Prediction Using a Novel Interaction-Based Graph Neural Network Framework.

ACS bio & med chem Au·2025
Same author

Impact of Persistent Endocrine-Disrupting Chemicals on Human Nuclear Receptors: Insights from In Silico and Experimental Characterization.

International journal of molecular sciences·2025

相关实验视频

Updated: Jan 7, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

15.5K

自动EpiCollect 2.0:一个基于Web的机器学习工具,用于个性化类癌症疫苗设计.

Clifford A Kim1, Nina Shelton1, Madhav Samudrala2

  • 1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20007, USA.

Molecules (Basel, Switzerland)
|December 31, 2025
PubMed
概括

自动EpiCollect 2.0自动化瘤特定变体识别,用于个性化癌症疫苗. 该软件通过简化基因分析和表位发现来加速有效的癌症疫苗的设计.

关键词:
在RNA测序过程中,RNA测序乳腺癌,乳腺癌.宫内皮质瘤是什么宫状状细胞癌是什么人类乳头瘤病毒人类乳头瘤病毒机器学习是机器学习.类疫苗疫苗的使用情况个性化癌症疫苗 个性化癌症疫苗三重阴性乳腺癌是什么

更多相关视频

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

1.7K
Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
09:28

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

12.0K

相关实验视频

Last Updated: Jan 7, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

15.5K
Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

1.7K
Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
09:28

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

12.0K

科学领域:

  • 基因组学和生物信息学
  • 免疫学和疫苗开发
  • 在瘤学瘤学.

背景情况:

  • 个性化癌症疫苗训练免疫系统对抗瘤抗原.
  • 以前用于识别瘤特定变异的方法是手动的,耗时的.
  • 自动EpiCollect 1.0加速了疫苗设计,但缺乏综合基因分析.

研究的目的:

  • 为癌症疫苗开发引入AutoEpiCollect 2.0,这是一款带有自动基因分析的增强软件.
  • 简化从单个瘤样本中识别和优先考虑瘤特异型变异.
  • 展示AutoEpiCollect 2.0在设计针对宫癌和乳腺癌的个性化类疫苗中的应用.

主要方法:

  • 自动EpiCollect 2.0集成RNA测序 (RNAseq) 数据用于变体确定.
  • 该软件交叉引用RNAseq数据以识别癌症特异性和预后基因变异.
  • 两项病例研究对宫平细胞癌和乳腺癌样本进行了研究.

主要成果:

  • AutoEpiCollect 2.0成功地确定了两种癌症类型的高潜力MHC I类和II类表位.
  • 在宫癌 (HSPG2,MUC5AC) 和乳腺癌 (BRCA2,AHNAK2) 中确定了关键的免疫原性表位.
  • 该软件减少了识别瘤抗原的时间,并简化了变异分析.

结论:

  • 通过自动化基因组分析,AutoEpiCollect 2.0显著提高了个性化癌症疫苗设计的效率.
  • 该工具通过分析频繁的基因变异,使患者特异性和人口级别的疫苗设计成为可能.
  • 自动EpiCollect 2.0 可作为一个免费的基于网络的疫苗设计工具.