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七年的沙门氏菌:变化的耐药性和临床见解

Cristina Mihaela Sima^1,2, Aida Corina Bădescu^1,2, Georgiana Buruiană^1,2

¹Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iași, Romania.

|December 31, 2025

概括

罗马尼亚的非伤寒型沙门氏菌 (NTS) 呈现出越来越多的抗西普洛素耐药性. 心血管并发症与NTS腹的更长的住院时间有关,这凸显了监测和有针对性的管理的必要性.

科学领域:

传染性疾病传染性疾病
微生物学微生物学
公共卫生公共卫生

背景情况:

非伤寒型沙门氏菌 (NTS) 是一个全球性的健康问题,原因是抗菌素耐药性和疾病负担的增加.
罗马尼亚的NTS数据有限,需要进行区域研究.

研究的目的:

调查罗马尼亚的NTS耐药性趋势和与疾病严重程度相关的临床因素.
提供第一个关于NTS相关腹的7年后期区域性分析.

主要方法:

从2018年1月到2024年12月,对698名实验室确认的NTS感染的住院患者进行了回顾性研究.
使用SPSS分析电子医疗记录中的患者数据,重点关注耐药性模式和临床结果.
统计分析以确定与长时间住院和侵入性感染相关的因素.

主要成果:

血清组D,B和C是最常见的NTS分离物.
显著每年增加的西普罗夫洛克萨辛耐药性 (OR = 1.21,p < 0.001).
心血管并发症独立与长时间住院 (>5天) 相关 (OR = 2.25,p = 0.007).
在2%的患者中观察到侵入性感染.

结论:

在罗马尼亚,NTS中日益增长的西普罗夫洛克萨辛耐药性是令人担忧的.
心血管相关疾病增加了严重NTS疾病的风险.
持续的监测和有针对性的管理策略对于控制NTS感染至关重要.

关键词:

东欧东欧东欧东欧诺基诺的化.通过食物传播的病原体住院治疗住院治疗侵袭性NTS是一种侵入性NTS.

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