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A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

在怀孕晚期的妇女中,阴道和肠道微生物群的比较表征,有或没有B组链球菌殖民

Shuang Song¹, Kaori Iino¹, Mako Nakamura¹

¹Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki 036-8562, Aomori, Japan.

|December 31, 2025

概括

孕妇的B组链球菌 (GBS) 定居与特定的阴道细菌转移有关,特别是增加*L. iners*. 这表明微妙的阴道微生物群变化,而不是肠道变化,可能表明GBS风险.

科学领域:

微生物学微生物学
产科和妇科产科和妇科
人类微生物组研究研究

背景情况:

怀孕期间的B组链球菌 (GBS) 定居构成新生儿感染的重大风险.
影响GBS殖民的微生物因素在很大程度上仍未确定.
了解这些决定因素对于周边风险分层至关重要.

研究的目的:

为了比较孕妇的阴道和肠道微生物群,有和没有GBS殖民.
识别与妊娠晚期GBS殖民相关的潜在微生物线索.
在GBS的背景下,探索阴道和肠道微生物群落之间的关系.

主要方法:

试点研究涉及43名日本孕妇 (35-37周怀孕).
使用16S rRNA (V3-V4) 测序分析阴道和便样本.
社区国家类型 (CST) 分类和差异丰度分析.

主要成果:

阴道微生物群在两组中都以乳酸菌为主.
具有GBS阳性的女性表现出对*L. iners*占主导地位的CST III的趋势,而对*L. crispatus*占主导地位的CST I的趋势较小.
像Prevotella,Atopobium和Gardnerella这样的品种在GBS阳性女性中显著丰富.
两组之间没有观察到肠道微生物多样性或组成的显著差异.

结论:

怀孕后期的GBS殖民与阴道微生物群的微妙变化有关,有利于L. iners和与细菌性阴道炎相关的细菌.
这些转变发生在一般的乳杆菌占主导地位的阴道环境中.
肠道微生物群的组成似乎没有受到GBS殖民的显著改变.
需要在更大的队列中进行进一步的研究,以确认从*L. crispatus*到*L. iners*的主导地位的转变作为预测标记.

关键词:

16S rRNA 测序的测序方法 B组的链球菌.牛乳杆菌的内置者牛乳杆菌克里斯帕图斯 (Lactobacillus crispatus) 是一种细菌.与细菌性阴道炎相关的细菌胆 ?? 阴性炎是一种胆 ?? 阴性炎.微生物群的多样性微生物群的多样性过早分娩过早分娩是什么

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