史蒂文斯-约翰逊综合征和Sjögren病中的肠道微生物组:与眼睛干燥的相关性
相关实验视频
Updated: Jan 7, 2026
07:52
Conjunctival Commensal Isolation and Identification in Mice
Published on: May 1, 2021
4.9K
Luciana Frizon1, Talita Trevizani Rocchetti1, André Frizon1
1Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, Botucatu Street 822, São Paulo 04023-062, Brazil.
Microorganisms
|December 31, 2025
概括
史蒂文斯-约翰逊综合征 (SJS) 患者的肠道微生物组显示出减少多样性和减少便细菌,与Sjögren病患者不同. 特定的肠道细菌与SJS中干眼严重程度相关.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
背景情况:
- 肠道微生物失调症与自身免疫性疾病有关.
- 史蒂文斯-约翰逊综合征 (SJS) 和Sjögren病 (SjD) 是自身免疫性疾病,可能与粘膜免疫有关.
- 干眼病 (DED) 是自身免疫性疾病中常见的一种表现.
研究的目的:
- 为了比较患有SJS,SjD和健康对照患者的肠道微生物组合.
- 在SJS患者中调查肠道微生物概况和干眼参数之间的相关性.
- 探索肠道微生物组在SJS和DED病变发生中的潜在作用.
主要方法:
- 试点探索性研究涉及10名SJS患者,10名SjD患者和20名健康对照.
- 16S V3-V4核糖体RNA基因区域的下一代测序 (NGS) 用于肠道微生物组的分析.
- 使用Silva数据库分析微生物组数据并评估干眼参数 (DEWS,NEI,TBUT).
主要成果:
- 与对照组相比,SJS患者的肠道微生物丰富度显著降低 (Chao1指数,p=0.01) 和Faecalibacterium的丰度较低 (p=0.048).
- 在SJS患者的特定肠道细菌种群与DED严重程度相关:克里斯森氏菌增加,DEWS减少 (p=0.04),Subdoligranulum增加,NEI得分减少 (p=0.04),Clostridia增加,TBUT更长 (p=0.009).
- SjD患者的肠道微生物组与健康对照组没有显著差异.
结论:
- SJS与明显的肠道微生物变化有关,包括减少多样性和便细菌枯竭.
- 在SJS患者的肠道微生物组组成与眼睛表面炎症和干眼严重程度相关.
- 肠道微生物组可能在SJS及其相关干眼症状的发病过程中发挥作用,需要进一步调查.
相关概念视频
01:17Gastritis-II: Pathophysiology
1.1K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.1K
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
708
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
708
01:30Inflammatory Bowel Disease II: Crohn's Disease
912
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
912
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
609
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
609
01:11Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
854
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
854