基于PCR和常规的便检测在住院的腹患者:诊断产量,临床影响和管理影响
Alina Boeriu1,2, Adina Andone1,2, Daniela Dobru1,2
1Gastroenterology Department, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.
Microorganisms
|December 31, 2025
概括
与传统方法相比,多重PCR显著改善了住院腹患者的肠道病原体检测. 这种快速检测有助于抗生素管理和临床决策.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 诊断技术 诊断技术 诊断技术
背景情况:
- 精确识别肠道病原体对于治疗住院患者急性腹至关重要.
- 传统的便检测往往缺乏用于全面检测病原体的灵敏度.
- 多重PCR提供快速和广泛的病原体识别.
研究的目的:
- 将多重PCR的诊断产量和临床影响与急性腹的成年住院患者的传统便诊断进行比较.
- 评估多重PCR对抗生素使用和患者结局的影响.
主要方法:
- 对267名患有急性腹的成年住院患者进行了回顾性多中心研究.
- 传统便诊断 (n=146) 和多重PCR与便培养 (n=121) 的比较.
- 对临床数据,诊断产量,抗生素利用率和临床结果的分析.
主要成果:
- 多重PCR显示了显著更高的诊断收益率 (77.7%对41.1%,p < 0.001),检测出更多的混合感染和各种病原体.
- PCR阳性与血淋淋的腹和脱水相关.
- PCR测试减少了不适当的抗生素使用 (OR 0.30),缩短了抗生素持续时间,增加了抗生素调整和停用.
- 在PCR组中,有更多的ICU入院和更长的住院时间,这表明病情更严重.
结论:
- 多重PCR增强了肠道病原体的检测,并支持住院腹患者的抗生素管理.
- 快速的多重PCR结果有助于更早地作出有针对性的临床决策,特别是在严重病例或并发症患者中.
- 该技术通过提供全面及及时的诊断信息,改善了传染性腹的管理.
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