肠道微生物组和新陈代谢特征与乳牛的耐热性相关
Mingxun Li1, Peng Chen1, Can Liu1
1Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Microorganisms
|December 31, 2025
概括
耐热的奶牛拥有肠道微生物和代谢物,支持能量平衡并减少氧化应激. 热敏奶牛表现出与压力相关的代谢模式,揭示了改善牛热弹性的关键机制.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 热压对奶牛的健康和生产力产生负面影响.
- 了解肠道微生物组与代谢物相互作用对于提高耐热性至关重要.
研究的目的:
- 为了研究与霍尔斯坦牛的耐热性相关的肠道微生物和代谢特征.
- 为了确定与耐热性相关的特定微生物种群和代谢物.
主要方法:
- 综合元基因组测序和非目标代谢学.
- 对耐热 (HT) 和耐热 (HS) 荷尔斯坦牛的肠道微生物群和代谢物的分析.
- 针对牛表型的入加权TOPSIS评分.
主要成果:
- 在HT奶牛中,特定的属 (例如, *Faecalimonas*, *UBA737*) 与能量和脂质代谢相关.
- 在HS牛中,有与脂多糖和糖脂生物合成相关的种群.
- 135种代谢物的丰度差异,其中甘油二酸盐和24(28) - 脱水素固醇具有很高的诊断价值 (AUC=1000).
- 已识别的微生物-代谢物网络 (例如, *Faecalimonas*-LysoPS, *UBA737*-甘油二酸盐),表明功能合.
结论:
- 耐热的奶牛表现出肠道微生物和代谢特征,促进能量平衡,膜重塑和氧化应激弹性.
- 热敏的奶牛表现出代谢模式表明压力.
- 结果揭示了热弹性的微生物代谢机制,并建议用于育种和管理的潜在生物标志物.
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