早期的人口因素塑造肠道微生物组模式 与罗塔病毒胃肠炎相关的严重程度
Eman R Abdelbary1, Mohammed Ramadan1, Ibrahim A Amin1
1Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Assiut 71526, Egypt.
Viruses
|December 31, 2025
概括
婴儿早期的生活因素,如分娩方式和养方式,显著改变了婴儿的肠道细菌,影响了轮状病毒胃肠炎 (RVGE) 的严重程度. 这突出了基于微生物群的干预措施的潜在目标,以改善RVGE结果.
科学领域:
- 微生物组研究 微生物组研究
- 儿童传染病 儿童传染病
- 肠道健康 肠道健康
背景情况:
- 轮状病毒胃肠炎 (RVGE) 是全球婴儿腹的主要原因.
- 肠道微生物群在RVGE中起着作用,但其与生命早期因素和疾病严重程度的相互作用尚不清楚.
研究的目的:
- 调查人口决定因素如何影响RVGE中的肠道微生物组组成和功能.
- 确定这些微生物组特征与RVGE临床严重程度之间的关系.
主要方法:
- 一项涉及165名0-12个月龄的婴儿 (120例RVGE,45例对照) 的病例控制研究.
- 使用了16S rRNA测序,统计建模和机器学习.
- 分析了人口因素对微生物组合和临床结果的影响.
主要成果:
- RVGE病例显示细菌多样性减少和与脱水严重程度相关的显著微生物组结构.
- 有益的细菌 (例如,阿克尔曼西亚,Faecalibacterium,Bifidobacterium) 被耗尽,而与炎症相关的种类 (例如,Escherichia-Shigella,Streptococcus) 被丰富.
- 与阴道分娩,母乳养的婴儿相比,剖腹产,配方奶粉养的婴儿具有失生性微生物组和更长的住院时间.
结论:
- 早期的人口因素塑造了婴儿肠道微生物组,影响了RVGE的严重程度和恢复.
- 研究结果表明,RVGE中风险分层的潜在生物标志物和基于微生物群的干预措施的目标.
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