艾普斯坦-巴尔病毒和人类乳腺瘤病毒在乳腺癌中的共同感染的全球流行和癌症风险:系统性审查和元分析
Abdelrahman A Karen1, Albara S Elkhalaf1, Omar Tluli1
1Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Viruses
|December 31, 2025
概括
爱斯坦-巴尔病毒 (EBV) 和人类乳头瘤病毒 (HPV) 联合感染在全球乳腺癌患者中越来越普遍. 这种共感染显示出与乳腺癌风险增加的显著关联,这表明这些瘤病毒的潜在作用.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 乳腺癌是全球女性癌症死亡的主要原因之一.
- 爱斯坦-巴尔病毒 (EBV) 和人类乳头瘤病毒 (HPV) 被认为是瘤病毒,在癌症发育中具有潜在的作用.
- 在EBV/HPV共感染和乳腺癌之间的关联仍在调查中.
研究的目的:
- 在乳腺癌患者中系统地审查和元分析EBV和HPV共感染的全球患病率.
- 调查EBV/HPV联合感染与乳腺癌风险之间的关联.
主要方法:
- 在PubMed,Scopus,Web of Science和Embase的系统文献搜索到2025年5月.
- 包括使用PCR检测乳腺组织样本中的EBV和HPV的研究.
- 应用随机效应模型来计算联合流行率和共同感染和乳腺癌风险的几率比率.
主要成果:
- 分析了16项涉及307项记录的研究,显示乳腺癌患者的EBV/HPV联合感染患病率为14%.
- 患病率因地区而异,从南美洲的6%到中东的22%,随着时间的推移,患病率呈上升趋势.
- 5.87 (95% CI: 2.31-14.93) 的概率比率表明EBV/HPV联合感染与乳腺癌风险之间存在显著的关联.
结论:
- 乳腺癌患者中EBV和HPV共感染的患病率在地理上是可变的,并且正在增加.
- 一个强大的统计学关联表明,EBV和HPV共感染在乳腺癌发病中的潜在作用.
- 这些发现强调了EBV和HPV疫苗对乳腺癌的潜在预防性影响.
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