SARS-CoV-2肺炎对慢性阻塞性肺部疾病的影响:在ICU患者中的比较研究
Duygu Kayar Calili1, Nihal Yuzbasioglu2, Melih Gaffar Gozukara3
1Department of Anesthesiology and Reanimation-Intensive Care, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara Bilkent City Hospital, Ankara 06800, Turkey.
患有慢性阻塞性肺病 (COPD) 的患者在感染SARS-CoV-2时面临更糟糕的结果. 重症慢性肺炎患者的死亡率较高,具有侵入性机械通风和高中性粒细胞与淋巴细胞比率预测死亡.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 慢性阻塞性肺病 (COPD) 是已知的SARS-CoV-2感染不良结果的危险因素.
- 慢性肺炎对重症SARS-CoV-2患者的具体影响需要进一步阐明.
研究的目的:
- 为了比较重症监护室 (ICU) 的临床和实验室资料,SARS-CoV-2肺炎患者有或没有先前存在的COPD.
- 为了确定COPD的SARS-CoV-2患者的死亡预测因素.
主要方法:
- 对1536名因SARS-CoV-2肺炎而入院的成年ICU患者的回顾性研究.
- 对一个COPD组 (n=253) 和一个非肺部疾病 (NPD) 组 (n=1283) 的比较.
- 对人口统计学,临床特征,疾病严重程度,停留时间,实验室值和生存结果的分析.
主要成果:
- 慢性肺炎患者年龄较大,疾病严重程度得分较高,并有更多的并发症.
- 慢性肺炎患者的侵入性机械通风 (IMV) 率更高,死亡率增加,住院时间更短.
- 增加的中性粒细胞与淋巴细胞比率 (NLR) 和IMV是COPD患者死亡率的显著预测因素.
结论:
- 慢性肺炎显著增加了严重病情的SARS-CoV-2患者的疾病负担和死亡率.
- 高的NLR和IMV独立地与这一群体的死亡风险增加有关.
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