蒙古的C型肝炎病毒感染:有关流行率,基因型分布和年龄特定风险因素的最新省级数据
Amgalan Byambasuren1,2, Myagmarjaltsan Baatarzorigt2, Munkhtuya Otgon3
1Department of Health Research, Graduate School, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, Mongolia.
Viruses
|December 31, 2025
概括
型肝炎病毒 (HCV) 仍然是蒙古的一个重大公共卫生问题,老年人和妇女的患病率更高. 关键的风险因素包括不安全的注射和传统做法,需要有针对性的预防策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 蒙古历来是全球肝炎C病毒 (HCV) 患病率最高的国家之一,过去估计超过15%.
- 在该地区,HCV感染构成了重大公共卫生挑战.
- 这项研究解决了对阿克汉海省HCV流行率和风险因素的最新数据的需求.
研究的目的:
- 确定阿克汉海省HCV感染的流行率和基因型分布.
- 确定与HCV感染相关的人口和暴露相关的风险因素.
- 为蒙古消除HCV的公共卫生战略提供信息.
主要方法:
- 一项以人口为基础的横截面研究,涉及蒙古阿克汉海省的2304名0-80岁居民.
- 血清样本进行抗HCV抗体 (ELISA) 和HCVRNA (PCR) 检测.
- 后勤回归分析用于识别HCV感染的独立风险因素.
主要成果:
- HCV抗体的流行率为12.0%,HCVRNA阳性为7.16%.
- 感染患病率随着年龄的增长而显著增加,女性患病率更高.
- 基因型1b占主导地位 (98.2%),发现了疗法,共享剃须刀使用,化品手术和不安全注射的显著关联.
结论:
- 在阿克汉海省,HCV感染仍然很普遍,特别是在老年人和妇女中.
- 基因型1b继续占主导地位,表明病毒基因分布稳定.
- 包括教育和实践监管在内的全面预防策略对于消除HCV的目标至关重要.
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