严重COVID-19幸存者的外周血液单核细胞的长期转录基因重编程揭示了亲瘤特征和与癌症相关的枢纽基因
Pelin Duru Cetinkaya1, Ozgecan Kayalar2,3, Vahap Eldem4
1Department of Pulmonary Medicine, Faculty of Medicine, Cukurova University, Adana 01790, Türkiye.
Viruses
|December 31, 2025
概括
严重的COVID-19感染可能通过长期改变血液细胞中的基因表达来促进癌症的发展. 这种持续的亲瘤特征表明癌症风险增加以及需要持续监测患者.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 严重的COVID-19 (冠状病毒疾病2019) 是一个全球性的健康危机.
- 潜在的长期健康后果,包括癌症风险,仍在调查中.
- 了解严重感染的分子影响对于患者管理至关重要.
研究的目的:
- 在严重的COVID-19后,调查周边血液单核细胞 (PBMC) 的长期转录变化.
- 为了确定这些变化是否与亲瘤性分子特征有关.
- 探索COVID-19感染与癌症发展或复发之间的联系.
主要方法:
- 从健康对照组和COVID-19患者 (有或没有肺炎) 中对PBMCs的RNA测序,感染后一年.
- 差异基因表达分析以确定显著的分子变化.
- 功能性丰富分析用于绘制受影响的生物通路.
- 在各种癌症类型中,Hub基因鉴定和生存分析.
主要成果:
- 严重的COVID-19患者在PBMC中表现出持续的亲瘤分子特征.
- 丰富的癌症相关途径包括亡,病毒性致癌和转录失调.
- 自基因SQSTM1/P62被确定为严重病例中的关键枢纽基因.
- 与COVID-19相关的枢纽基因的高表达与特定癌症 (例如,上腺皮质癌,膀癌,质瘤) 的预后不佳相关.
结论:
- 严重的COVID-19感染可能会创造一个有利于癌症发展或复发的系统性环境.
- 对于有严重COVID-19病史的人来说,长期的瘤监测是必不可少的.
- 确定特定的分子标可以阐明COVID-19和癌症风险之间的关系.
相关概念视频
Cancer-Critical Genes I: Proto-oncogenes
11.1K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.1K
Cancer Stem Cells and Tumor Maintenance
5.8K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.8K
lncRNA - Long Non-coding RNAs
9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
Cancer-Critical Genes II: Tumor Suppressor Genes
9.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.3K
Cancers Originate from Somatic Mutations in a Single Cell
14.5K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
14.5K
Mechanisms of Retrovirus-induced Cancers
6.8K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
6.8K


