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Updated: Jan 7, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

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阿尔法折叠-随机步行和阿尔法折叠-组合:采样替代蛋白质构造与阿尔法折叠的扰乱版本

Ishan Taneja1, Manuel A Llanos1, Monica L Fernández-Quintero1

  • 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.

Journal of chemical information and modeling
|December 31, 2025
PubMed
概括

新的机器学习方法AlphaFold-RandomWalk和AlphaFold-Ensemble产生了多样化的蛋白质结构. 将这些与分子动力学模拟相结合,可以有效地探测蛋白质结构异质性.

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Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
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