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miRNA-337-3p和矩阵金属蛋白酶-9:口腔状细胞癌的表达模式和宫淋巴结转移的预后值

Hongyan Xu¹, Peng Zhang¹, Ying Yang¹

¹Department of Stomatology, Shaanxi Provincal People's Hospital, Xi'an, Shaanxi Province, China.

Orthodontics & craniofacial research

|December 31, 2025

概括

矩阵金属蛋白酶9 (MMP-9) 和miRNA-337-3p表达与口腔状细胞癌 (OSCC) 中的宫淋巴结转移有关. 米RNA-337-3p作为瘤抑制剂,可能抑制OSCC入侵和转移.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

口腔状细胞癌 (OSCC) 是一种普遍存在的恶性瘤.
了解像矩阵金属蛋白酶9 (MMP-9) 和微RNA这样的分子标记物对于OSCC进展至关重要.
米RNA-337-3p已与各种癌症有关,但其在OSCC中的作用需要进一步阐明.

研究的目的:

研究OSCC组织中MMP-9和miRNA-337-3p的表达水平.
分析这些分子与OSCC患者临床病理特征之间的相关性.
确定miRNA-337-3p在OSCC中的潜在临床意义和功能作用.

主要方法:

实时光定量逆转录PCR被用于量化30个OSCC患者样本和相邻的正常组织中的miRNA-337-3p表达.
免疫组织化学被用来评估MMP-9表达.
进行了统计分析,以将表达水平与临床病理参数相关联,包括淋巴结转移状态.

主要成果:

与正常组织相比,OSCC组织中的MiRNA-337-3p表达显著下调 (p <0.05).
在OSCC组织 (83.33%) 中,MMP-9阳性率高于邻近的正常组织 (36.67%).
与没有淋巴结转移 (N1+N2阶段) 的患者 (p <0.05) 相比,OSCC患者的miRNA-337-3p水平较低 (p <0.05).

结论:

在OSCC中,MMP-9和miRNA-337-3p表达都与宫淋巴结转移有关.
在OSCC中,MiRNA-337-3p表现出抑制瘤的特性.
MiRNA-337-3p可能在抑制OSCC细胞入侵和转移方面发挥作用.

关键词:

临床意义临床意义矩阵金属蛋白酶-9的基因.微RNA-337-3p3p的使用情况.口腔状细胞癌的癌症.

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