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布普伦诺芬对健康狗眼睛参数的影响

James C Pohl1, Cassin W Gonzales2, Ruby B Goldenberg1

  • 1Veterinary Eye Clinic, Los Angeles, California, USA.

Veterinary ophthalmology
|December 31, 2025
PubMed
概括

在狗中,静脉注射布普伦诺芬 (0.02 mg/kg) 导致瞳孔大小和眼内压力发生显著变化. 在患有影响这些眼部参数的疾病的狗中使用这种阿片类止痛药时,建议谨慎使用.

关键词:
布普伦诺啡因是一种狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗眼内压力 眼内压力客观参数是客观的参数.瞳孔的大小 瞳孔的大小主观参数是主观的参数.

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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