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Updated: Jan 7, 2026

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脑脊液代谢物和内动脉瘤之间的因果关系的遗传证据:双向的双样本孟德尔随机化研究

Rong Xiao1, Wen Zhang1

  • 1Department of Neurology, Yichun People's Hospital, Yichun, Jiangxi, China.

The International journal of neuroscience
|December 31, 2025
PubMed
概括

这项研究使用了门德尔的随机化来发现与内动脉瘤 (IA) 相关的脑脊液 (CSF) 代谢物. 几种代谢物被确定为保护性或风险因素,为IA提供了潜在的生物标志物.

关键词:
门德尔的随机化双向分析是一种双向分析.大脑脊髓液的代谢物.头骨内动脉瘤是什么意思

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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