代谢模式与功能衰退之间的性别特定关联:中国东南部的一项回顾性队列研究
Zhaoyang Zhao1, Xiaoqing Ni1, Jiale Xu1
1Department of Epidemiology and Biostatistics, School of Public Health and Nursing, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People's Republic of China.
Journal of multidisciplinary healthcare
|December 31, 2025
概括
代谢异常在患有高血压,禁食葡萄糖受损或边缘性脂质失调的妇女和患有高血压和禁食葡萄糖受损的男性中加速功能下降. 早期治疗是保护脏的关键.
科学领域:
- 心血管和新陈代谢健康
- 科和脏疾病研究研究
- 公共卫生和流行病学
背景情况:
- 代谢异常,包括高血压,失脂症和高血糖症,是普遍存在的,并与各种健康问题有关.
- 慢性病 (CKD) 影响全球数百万人,需要对其早期风险因素进行研究.
- 了解性别特定的代谢模式及其对功能的影响对于有针对性的干预至关重要.
研究的目的:
- 在中国人口中定义性别特定的代谢概况.
- 为了研究这些代谢模式和功能下降 (eGFR) 之间的关联,在没有先前存在的CKD的个体中.
- 识别具有较高功能恶化的风险的代谢模式.
主要方法:
- 隐形形状分析被用来根据胆固醇,血压和葡萄糖水平将参与者分为不同的代谢模式.
- 用通用估计方程 (GEE) 分析了代谢模式对估计的膜过率 (eGFR) 下降的纵向影响.
- 该研究包括来自中国社区健康调查 (2012-2018) 的8511名参与者,至少进行了三次后续调查.
主要成果:
- 妇女被分为没有代谢异常 (NMA),高血压损伤的禁食葡萄糖-边缘性脂质不良症 (HIB) 和高血压-高血糖-边缘性脂质不良症 (HHB). 与NMA相比,HIB和HHB组的功能下降风险显著更高 (分别为1.33x和1.41x).
- 男人被分为NMA,高血压-减弱的禁食葡萄糖-正常的总胆固醇 (HIN) 和高血压-高血糖-正常的总胆固醇 (HHN). 与NMA相比,HIN组每年功能下降风险增加26%,HHN组没有观察到与时间相关的显著关联.
- 在特定的代谢异常组中的两种性别都表现出了与NMA相比,随着时间的推移eGFR的下降速度更快.
结论:
- 具有HIB和HHB代谢模式的女性,以及具有HIN的男性,面临功能下降的加速风险.
- 这些发现强调了性别特异性代谢分析在评估病风险方面的重要性.
- 代谢异常的积极管理对于保持脏健康和预防CKD进展至关重要.
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