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抑制A2AR可以缓解由腺介导的血细胞分化抑制

Paola Tieppo1, Hussein Shehade1, Chiara Martinoli1

  • 1iTeos Therapeutics, Gosselies, Belgium.

Frontiers in immunology
|December 31, 2025
PubMed
概括

高氨酸水平通过A2AR抑制B细胞通过A2AR成抗体分泌细胞 (ASC) 的成熟. A2AR对抗剂inupadenant完全逆转这种免疫抑制,恢复瘤中的ASC.

关键词:
A2AR A2AR A2AR A2AR A2AR A2AR A2B 细胞 B 细胞 B 细胞氨酸 (Adenosine) 是一种氨酸.癌症 癌症 癌症 癌症 癌症血细胞是血细胞的组成部分.

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