自然多糖的抗炎作用:分子机制和纳米治疗应用
Jihao Yang1, Kai Xiong2, Tengzhen Li2
1School of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Frontiers in immunology
|December 31, 2025
概括
自然的多糖类通过调节关键路径来对抗炎症. 纳米化增强了它们的溶解性和有效性,改善了炎症性疾病的生物可用性和治疗潜力.
科学领域:
- 生物化学和药理学 生物化学和药理学
- 纳米技术 纳米技术
- 免疫学 免疫学 免疫学
背景情况:
- 慢性炎症是心力衰竭 (HF) 和关节炎等疾病的基础.
- 天然多糖类通过调节信号通路 (NF-κB,MAPK,TLR) 和减少促炎细胞因子 (TNF-α,IL-1β,IL-6) 具有抗炎性质.
- 限制包括水溶性差和酶降解,阻碍生物可用性.
研究的目的:
- 审查天然多糖的抗炎机制.
- 探索纳米化策略,以提高多糖的有效性.
- 评估基于多糖的疗法的临床翻译潜力.
主要方法:
- 文献综述侧重于炎症,多糖类的抗炎作用和纳米化技术.
- 对信号通路 (NF-κB,MAPK,TLR,Nrf2/HO-1) 和细胞因子调节的分析.
- 对纳米化对溶解性,生物可用性,向性和治疗结果的影响的评估.
主要成果:
- 纳米化改善了多糖的水性分散性,并减少了酶分解.
- 纳米粒子增强了准效率 (EPR效应,带修饰) 和治疗效果.
- 纳米化增强了对促炎途径的抑制,并激活了抗氧化途径 (Nrf2/HO-1).
结论:
- 纳米化显著提高了天然多糖的抗炎功效和生物可用性.
- 基于多糖的纳米疗法为治疗炎症疾病提供了有前途的潜力.
- 本次审查为推进这些疗法的临床应用提供了一个框架.
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