宫外脂肪分布和南亚人的不利肌肉组成:来自英国生物银行的研究结果
Sanaa Tejani1, Jennifer Linge2,3, Ian Neeland4
1University of Texas Southwestern Medical Center, Department of Internal Medicine, Dallas, TX, USA.
American journal of preventive cardiology
|December 31, 2025
概括
与欧洲人相比,南亚人体脂较高,肌肉体积较小,这增加了心脏代谢疾病的风险. 这些身体组成的差异可能解释了南亚人2型糖尿病风险的增加.
科学领域:
- 心血管疾病的研究研究.
- 代谢健康研究研究.
- 身体组成分析分析.
背景情况:
- 与其他族群相比,南亚人 (SA) 面临患心脏代谢疾病的风险更高.
- 在大型SA队列中,对身体组成概况 (BCP) 进行了有限的详细分析,包括子宫外脂肪和肌肉组成.
研究的目的:
- 为了比较南亚人 (SA) 和白人欧洲人 (EUR) 之间的身体组成概况 (BCP).
- 调查与匹配的欧元相比,在2型糖尿病 (T2D) 的SA中BCP差异.
主要方法:
- 利用英国生物库的MRI数据进行BCP分析.
- 与SA (n=397) 与年龄,性别,身高和体重相匹配的欧元 (5:1比率) 相比.
- 还将SA与T2D (n=66) 与匹配的EUR (3:1比率) 相比较.
主要成果:
- 与欧盟相比,SAS显示内脏脂肪组织,皮下脂肪组织,肝脂肪和肌肉脂肪透率 (MFI) 显著增加.
- 此外,SA还具有较低的肌肉体积和较高的不良肌肉组成 (19.9%与7.9%) 的患病率.
- 经过对生活方式和社会经济因素进行调整后,这些差异仍然存在,但SA患有T2D的BCP与EUR患有T2D的BCP相似.
结论:
- 南亚人积累了更多的内脏,肝脏和肌肉脂肪,肌肉体积比欧洲人少.
- 这些身体组成的差异可能会导致SAS中T2D和动脉瘤结局的风险增加.
- 促进健康体重的生活方式干预可以通过改善身体组成来减轻SA中的心脏代谢风险.
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