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Updated: Jan 7, 2026

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
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Published on: July 15, 2025

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乳腺癌细胞系中胎儿胰岛素受体的mRNA和蛋白质表达

Xihong Zhang1, Albert Barrios1, LeeAnn Higgins2

  • 1Masonic Cancer Center, University of Minnesota.

bioRxiv : the preprint server for biology
|December 31, 2025
PubMed
概括

乳腺癌细胞过度表达胰岛素受体异型A (IR-A). 这项研究证实了乳腺癌中的IR-A蛋白表达,这表明IR-A在瘤生物学中的关键作用.

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Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
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