哺乳动物和鸟类的长寿并行选择.
bioRxiv : the preprint server for biology
|December 31, 2025
概括
科学家在长寿哺乳动物和鸟类中发现了在积极选择下共享的遗传通路和基因,这表明了长寿的古老,保存的工具包. 这意味着跨越多种脊椎动物血统的延长寿命的融合进化.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 衰老的研究研究.
背景情况:
- 在脊椎动物中,衰老是普遍的,但寿命有很大差异.
- 长寿物种在进化上是分散的,这表明长寿的重复起源.
- 之前的研究集中在短寿命的生物,忽视了自然长寿的脊椎动物.
研究的目的:
- 进行第一个全基因组对长寿哺乳动物和鸟类选择压力的调查.
- 确定这些多样化的种类中长寿的共同遗传机制.
- 为了研究延长寿命的融合进化.
主要方法:
- 积极和净化选择的全基因组调查.
- 数百种长寿哺乳动物和鸟类的比较基因组学.
- 这是一种新的方法来检测收的正选择.
主要成果:
- 在异常长寿的哺乳动物和鸟类的净化选择下确定了广泛的共享途径网络.
- 在长寿哺乳动物和鸟类的平行正选择下发现了16个基因,涉及到衰老的标志.
- 在积极选择下发现与胆固醇代谢,氧化应激和自相关的基因.
结论:
- 选择签名中的惊人的相似之处表明,一个深度保存的,古老的长寿遗传工具包.
- 证据支持通过共享和修改的遗传机制延长寿命的融合进化.
- 确定了新的候选基因和未来衰老研究的途径.
相关概念视频
Convergent Evolution
31.3K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
31.3K
Limits to Natural Selection
33.9K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
33.9K
Types of Selection
43.7K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
43.7K
Multi-species Conserved Sequences
4.6K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.6K
Speciation Rates
22.5K
Overview
22.5K
Mate Choice
11.5K
Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
11.5K


