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Updated: Jan 7, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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在Allosteric站点的PIP2绑定阻止了人类棒CNG通道中的激活

Taehyun Park, Crina M Nimigean

    bioRxiv : the preprint server for biology
    |December 31, 2025
    PubMed
    概括

    酸-4,5-双酸盐 (PIP2) 通过降低它们开放的概率来抑制人体棒循环核酸门 (CNG) 通道. 这种结构机制解释了PIP2如何控制棒光受体中的光敏感性.

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