通过 Lactobacillus paracasei 和 Clopidogrel 的结合抑制血栓形成
1Department of Pharmacy, Shandong Provincial Third Hospital, Jinan, Shandong, 250031, People's Republic of China.
International journal of general medicine
|December 31, 2025
概括
乳杆菌帕拉凯西 (LP) 可能通过调节肠道微生物群,改善肠道屏障功能和减少炎症来影响克洛皮多格勒 (CLP) 的疗效. 这种组合疗法显示出增强抗血栓效应的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- * * 乳酸菌 (Lactobacillus paracasei* (LP)) 可能会影响克洛皮多格雷尔 (CLP) 的有效性.
- *了解这种相互作用对于优化抗血小板治疗至关重要.
研究的目的:
- * 为了研究LP和CLP在老鼠模型中对血栓形成的联合作用.
- * 探索对血小板功能,凝血,肠道微生物群和肠道屏障的影响.
主要方法:
- *斯普拉格-道利大鼠被分为对照组,LP,CLP,LP+CLP (治疗前) 和CLP+LP (治疗后) 组.
- *大鼠每天接受CLP (6.75 mg/kg) 和LP (10 CFU) 的剂量,持续14天.
- *评估血液药物度,血小板功能,血栓形成,炎症因素,肠道微生物群,SCFA,TMAO和粘膜屏障完整性.
主要成果:
- * 联合LP和CLP治疗降低了血液中的AM和CA度,同时增加了血小板聚合 (MPA) 和反应指数 (PRI).
- *血栓形成时间延长,血栓重量减少,抑制率增加.
- *LP调节肠道微生物群,增加SCFA和减少TMAO,同时改善肠道屏障功能 (ZO-1,奥克卢丁,P-gp表达).
- *炎症标志物 (TNF-α,IL-1β) 和血栓形成标志物 (P-selectin,GPIIb/IIIa,D-dimer) 显著减少.
结论:
- *LP可以通过调节肠道微生物群,保护肠道屏障和减少炎症来提高CLP的疗效.
- *联合治疗似乎抑制了血小板激活,并改善了凝血功能.
- *需要进一步的研究才能充分阐明这种相互作用的潜在机制.
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