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与恶性瘤相关的活跃结核病风险:在第三级护理医院进行了为期4年的回顾性研究

Priyamvada Roy¹, Kiran Bala¹, Jaya Biswas¹

¹Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

South Asian journal of cancer

|December 31, 2025

概括

结核病 (TB) 是癌症患者的重大风险,特别是那些患有肺癌,白血病,胃肠道和泌尿生殖系统癌症的人. 在这些高风险癌症人群中,早期查和结核病治疗对于降低死亡率至关重要.

科学领域:

在瘤学瘤学.
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

结核病 (TB) 构成了全球重大公共卫生挑战.
癌症患者面临结核病再激活或再感染的风险较高.
这项研究研究了结核病发病率和结果在第三级护理医院环境.

研究的目的:

评估正在接受治疗的癌症患者的结核病 (TB) 发生率.
为了确定特定的癌症类型,具有较高的结核病共感染风险.
评估诊断方法的有效性和患者的治疗结果.

主要方法:

从怀疑结核病的癌症患者的临床样本进行了回顾性分析.
使用了Ziehl-Neelsen (ZN) 染色,GeneXpert MTB/RIF (Gx),TB聚合酶链反应 (PCR) 和液体培养 (MGIT 960).
使用Stata 14.0进行的统计分析与Pearson的千平方测试.

主要成果:

在906名患者中,42名 (4.64%) 被诊断为结核病患者.
基因Xpert (10.53%) 和PCR (13.51%) 的检测率高于ZN染色 (1.37%) 和MGIT培养 (6%).
肺癌 (28%),白血病 (25%) 和胃肠道/尿道癌 (每一个为13%) 在结核病阳性患者中最常见. 霍奇金淋巴瘤的死亡率最高 (75%).

结论:

活性结核病在癌症患者中普遍存在,特别是那些患有肺癌,白血病,胃肠道和泌尿生殖系统癌症的人.
霍奇金淋巴瘤患者与结核病相关的高死亡率强调需要保持警.
对于高风险癌症患者,建议在癌症诊断时和治疗期间定期进行针对性结核病查.

关键词:

基因Xpert 是一个专家.在MGIT 96060上.结核病的PCR是TB的PCR.齐尔·尼尔森 (ZiehlNeelsen) 没有留下一个污点.肺癌是一种肺癌.

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