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儿童肺气管的可逆性和特定的呼吸道阻力
Nicole Beydon1, Cécile Du Boisbaudry2, Christophe Delclaux3
1Sorbonne Université, APHP, Hôpital Armand Trousseau, Unité Fonctionnelle d'explorations fonctionnelles respiratoire et somnologie; INSERM U938, Centre de Recherche Saint Antoine, Paris, France.
ERJ open research
|December 31, 2025
概括
患有喘的儿童的气道阻力 (Raw) 和特定气道阻力 (sRaw) 逆转率的最佳切断值约为基线的-35%. 电子热补偿可能需要较低的切断值来准确评估1秒内强制呼气体积的可逆性 (FEV1).
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 飞气道阻力 (Raw) 和特定气道阻力 (sRaw) 对于评估无法进行螺旋计的儿童的肺功能至关重要.
- 对于使用这些方法的显著可逆性截止值,没有确立的共识.
研究的目的:
- 确定最佳的Raw和sRaw截止值,以检测1秒内显著的强迫呼气体积 (FEV1) 在喘儿童中的可逆性.
- 比较带有和没有电子热补偿的切断线.
主要方法:
- 对一大批喘儿童进行了回顾性分析,这些儿童在没有电子热补偿的情况下使用喘息进行了测试.
- 接收器操作特征 (ROC) 曲线分析以确定最佳切线.
- 对一个较小的队列进行了分析,该队列使用了带有电子热补偿的潮呼吸囊造影测试.
主要成果:
- 截止值为-34.4%的原料和-36.0%的sRaw (从基线) 有效地发现了显著的FEV1可逆性没有热补偿 (70-73%的特异性).
- 将可逆性表达为预测值的百分比并没有提高准确性,并且需要更大的切断值.
- 使用电子热补偿,建议采用较低的切断值 (-25%的基线),灵敏度和特异性从63%到70%不等.
结论:
- 原始和sRaw可逆性截止值约为基线的-35%是有效的确定FEV1在儿童中的可逆性.
- 使用预测值的百分比并不能为可逆性评估提供额外的准确性.
- 电子热补偿可能需要较低的切割值来进行准确的评估.
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