肥胖和低血清比利鲁宾总度之间的关联:一个回顾性,横截面研究
Trishna Parikh1, Fariha Hameed2, Sumaiya Islam3
1Department of Internal Medicine Case Western Reserve University/University Hospitals of Cleveland Cleveland Ohio USA.
较高的体重指数 (BMI) 和腰围 (WC) 与女性较低的总 bilirubin (TBili) 水平有关. 这种联系表明,TBili可能是肥胖相关健康风险的生物标志物.
科学领域:
- 代谢健康 代谢健康
- 生物标志物 生物标志物
- 肥胖问题研究研究
背景情况:
- 知名的抗氧化剂和抗炎剂比利鲁,与脂肪有相反的关系.
- 脂肪水平对总胆红素 (TBili) 度的确切影响需要进一步阐明.
研究的目的:
- 调查身体质量指数 (BMI) 和腰围 (WC) 与低TBili度之间的关联.
- 评估这些协会中的性别特异性差异.
主要方法:
- 利用了来自1999-2018年国家健康和营养检查调查的13,953名成年人 (年龄≥20岁) 的数据.
- 排除了肝酶升高,高酒精消耗,铁过载,贫血,高TBili,低白蛋白或阳性肝炎血清学结果的参与者.
- 采用多变量逻辑回归来分析基于BMI和WC类别的低TBili (<0.4 mg/dL) 的几率,按性别分层.
主要成果:
- 体重指数≥27.5的女性,与体重指数在23到25之间的女性相比,低TBili的几率增加了42%.
- 体重指数正常但体内值升高 (≥88厘米) 的女性患低结核病的几率显著增加 (OR: 2.74).
- 过去一年的BMI≥35和终身最大BMI≥25独立地与女性的低TBili相关;在男性中,类似的趋势并不显著.
结论:
- 较高的BMI和WC,即使BMI正常,也与女性患低TBili的可能性更高有关.
- 这些发现表明,低TBili可能作为临床肥胖及其相关健康影响的间接生物标志物.
- 建议进行进一步的研究,以探索低TBili对心脏代谢疾病风险和死亡率的长期影响.
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