COVID-19感染改变了精神病患者的P300延迟:一个回顾性队列研究
Xiaofeng Jiang1, Shunqi Qiu2, Weiwei Wang1
1The Seventh People's Hospital Affiliated Mental Health Center, Medical College of Shaoxing University Shaoxing Zhejiang China.
在精神病患者中,COVID-19感染暂时恶化了认知功能,长时间P300事件相关潜在延迟表明了这一点. 这种与注意力和工作记忆相关的效应独立于性别或抗精神病剂量,表明直接的神经影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
背景情况:
- 随着COVID-19的流行,人们对心理健康状况的个体的神经学影响产生了担忧.
- 在病毒感染期间,精神病患者的认知功能特别脆弱.
- P300事件相关潜力 (ERP) 延迟作为注意力和工作记忆的神经生理学标记.
研究的目的:
- 量化COVID-19感染对精神病患者P300延迟的影响.
- 探索P300延迟变化与人口/临床因素之间的潜在关联.
- 在这个人群中调查COVID-19感染后认知功能的时间动态.
主要方法:
- 一项回顾性队列研究,涉及19名精神病医院住院患者,他们被诊断患有包括精神分裂症在内的疾病.
- 进行了四次听觉奇怪P300评估:感染前 (T1),感染后1周 (T2),感染后大约2个月 (T3) 和3个月 (T4).
- 使用温室-盖塞校正的重复测量ANOVA分析了延迟变化;子组分析检查了性别和抗精神病剂量的影响.
主要成果:
- 观察到时间对P300延迟的显著主要影响 (p=0.002),表明评估期间的变化.
- P300延迟在T3 (338.77毫秒) 达到顶峰,显示出与基线T1 (335.75毫秒; p=0.030) 相比显著增加.
- 与T1 (p=0.020) 相比,在T4 (337.68毫秒) 中延迟仍然较高,性别或抗精神病剂量没有显著影响.
结论:
- 在精神病患者中,COVID-19感染显著延长了P300延迟时间,这表明注意力处理中的暂时障碍.
- 观察到的效果似乎独立于性别或药物剂量,指向直接的神经机制.
- 到T4部分恢复表明COVID-19相关认知缺陷的潜在可逆性,这与康复监测有关.
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