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乳酸和乳酸化在椎间盘退化中的作用

Yadong Liu^1,2, Jihao Yang³, Zihui Wang¹

¹Second Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Kunming, China.

Frontiers in molecular biosciences

|December 31, 2025

概括

椎间盘细胞通过产生乳酸盐来适应低氧,从而导致退化. 通过乳酸脱酶 (LDHs) 和单碳酸盐输送体 (MCTs) 准乳酸代谢提供了治疗潜力.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
生物医学工程生物医学工程

背景情况:

椎间盘 (IVD) 由于无血管性,具有低毒的微环境,促进无氧糖解和乳酸积累.
乳酸,一个关键的代谢副产品,显著影响细胞分化和命运在生理和病理条件,包括退行性疾病.

研究的目的:

审查乳酸和乳酸化在椎间盘退化 (IVDD) 中的关键作用.
探索针对乳酸代谢的治疗策略,以改善IVDD的治疗结果.

主要方法:

文献综述侧重于细胞代谢,乳酸信号和IVD中的乳酸化.
对乳酸脱酶 (LDH) 和单碳酸盐载体 (MCT) 在IVDD中的影响现有证据的分析.

主要成果:

乳酸积累是缺氧IVD微环境的标志,有助于IVDD的进展.
乳酸调节细胞信号通路,促进乳化,影响细胞命运.
针对LDHs和MCTs为IVDD提供了一个有前途的治疗途径.

结论:

了解乳酸调节和乳化对于减轻IVDD至关重要.
调节乳酸代谢为治疗椎间盘退化提供了重要的治疗潜力.

关键词:

功能功能功能功能功能干预策略干预策略椎间盘退化椎间盘退化乳酸乳酸是一种乳酸.乳化乳化乳化代谢代谢代谢代谢

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