夜班工作和患乳腺癌和前列腺癌的风险:系统审查和元分析,2012-2023年
Meritxell Soler-Saña1, Montserrat Puiggené-Vallverdú1, Pere Godoy1
1Hospital Universitari Santa Maria. Gestió de Serveis Sanitaris. Lleida. Spain.
Anales del sistema sanitario de Navarra
|December 31, 2025
概括
夜班工作与前列腺癌风险的关联较弱,特别是暴露时间较长. 然而,没有发现乳腺癌与乳腺癌有一致的联系,这表明需要进一步研究才能获得确的证据.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 国际癌症研究机构将夜班工作归类为可能的人类致癌物 (2A组).
- 关于夜班工作与癌症风险之间的关联的现有证据需要更新分析.
研究的目的:
- 系统地审查和综合夜班工作与患乳腺癌和前列腺癌的风险之间的联系的证据.
主要方法:
- 在PubMed和Web of Science进行了全面的文献搜索.
- 包括的研究是病例控制或队列研究,有100名参与者,评估夜间工作是乳腺或前列腺癌的风险因素,并符合质量标准 (纽卡斯尔-太华尺度得分=6).
- 数据综合遵循PRISMA指南,评估异质性和研究质量.
主要成果:
- 对21项研究 (586,890名参与者) 的分析显示,只有在队列研究中,夜班工作和乳腺癌风险之间存在显著联系 (总体RR=0.82;<10年RR=0.75).
- 对于前列腺癌,病例对照研究显示了相关性 (OR=1.14),观察到的显著风险为=10年的暴露 (RR=2.20,OR=1.16).
- 研究质量一般可接受到中度,乳腺癌分析中发现了大量的异质性.
结论:
- 观察到夜班工作与前列腺癌风险之间存在微弱的关联,特别是长期暴露 (>=10年).
- 在夜班工作和乳腺癌风险之间没有发现一致的关联.
- 这些发现是不确定的,强调了需要继续在这一领域的研究.
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