在慢性鼻炎中对后鼻神经切除术后果的伊普拉响应的预测值
Sainiteesh Maddineni1, Peter H Hwang1, Noel F Ayoub1
1Department of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Palo Alto, 94304, California, USA.
概括
响应ipratropium鼻雾剂的患者可能会从室内后鼻神经 (PNN) 切除中看到更好的结果. 然而,ipratropium反应并不能预测手术PNN神经切除术的结果,因为响应者和不响应者都可能受益.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 鼻科 鼻科是指鼻科的专家.
- 医疗器械 医疗器械
背景情况:
- 慢性鼻炎显著影响生活质量,尽管经过医疗管理,但经常持续存在.
- 后鼻神经 (PNN) 程序为耐火性慢性鼻炎提供了有效的治疗选择.
研究的目的:
- 为了调查患者对ipratropium鼻喷剂的反应是否预测PNN干预后的结果.
- 为了比较手术PNN神经切除与在办公室PNN切除的疗效,与ipratropium反应相关.
主要方法:
- 在2013年1月至2025年6月期间接受治疗的81名慢性鼻炎患者的回顾性评估.
- 这些患者之前曾经尝试过ipratropium鼻雾剂,并且接受了PNN手术神经切除术或室内切除术 (冷疗法/射频).
- 结果使用SNOT-22问卷进行评估,重点关注鼻科症状改善和临床有意义改善率 (MCID).
主要成果:
- 无论是PNN手术神经切除术还是办公室内切除术,都显著改善了SNOT-22鼻科子域得分.
- 对于在办公室内PNN切除,ipratropium响应者显示显著更高的MCID率 (64.7%) 和症状改善与非响应者 (27.8%) 相比.
- 手术PNN神经切除对ipratropium响应者和不响应者都带来了好处,两组之间的MCID率没有显著差异.
结论:
- 对ipratropium的积极反应可能表明更高的可能性受益于在办公室PNN废除技术.
- 伊普拉的反应不是手术PNN神经切除术后结果的可靠预测指标.
- 与手术神经切除相比,在基于ipratropium反应的患者选择中,室内PNN切除似乎更有选择性.
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