儿科败血症的神经病理解剖发现:一个双中心的回顾性研究
Alicia M Alcamo1,2,3, Leora Lieberman1, Nora Sherry4
1Division of Critical Care Medicine, Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, Philadelphia, PA.
概括
败血症经常导致大脑损伤,大多数患者显示急性神经病理发现. 进一步的研究对于开发治疗败血症引起的脑损伤的有效方法至关重要.
科学领域:
- 神经学 神经学
- 病理学 病理学 病理学
- 儿科 儿科 儿科
背景情况:
- 败血症是一种危及生命的疾病,与显著的发病率和死亡率有关.
- 急性脑功能障碍是败血症的常见并发症,但其潜在的病理生理学仍然不太了解.
- 关于发生在败血症儿童中的特定神经病理变化的数据有限.
研究的目的:
- 为了调查死于败血症的儿童的神经病理学发现.
- 在儿童群体中识别与败血症相关的常见的大脑和微观大脑异常.
- 探索临床因素和神经病理结果之间的潜在相关性.
主要方法:
- 两家大型儿童医院的回顾性队列研究.
- 在十年内对儿科败血症病例的神经病理解剖数据的分析.
- 对中央神经系统 (CNS) 大体和显微镜检查结果的审查.
主要成果:
- 在57名败血症患者中,有86%的人至少有一次急性神经病理发现.
- 常见的发现包括大脑 (39%),腹腔 (39%),出血 (30%),神经元损伤 (45%) 和心脏病发作 (25%).
- 死亡前的中枢神经系统感染与有关,而缺乏并发症与和神经元损伤相关.
结论:
- 神经病理异常在儿科败血症病例中很普遍.
- 了解这些病理对于开发有针对性的干预措施至关重要.
- 需要进一步的研究来阐明与败血症相关的大脑损伤的机制,并为治疗策略提供信息.
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