维生素D状态与夜间下尿道症状之间的关联:综合分析
Zihan Ye1,2,3,4,5,6,7,8, Hongsong Chen1,2,3,4,5,6,7,8, Qiang Zhang1,2,3,4,5,6,7,8
1Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, 401122, China.
Nutrition reviews
|December 31, 2025
概括
维生素D缺乏会显著增加夜间下尿路症状 (nLUTS) 的风险. 补充剂可能会降低nLUTS,表明维生素D评估可以帮助管理.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 新兴证据将维生素D水平与夜间下泌尿道症状 (nLUTS) 联系起来,但这些发现是不一致的.
- 维生素D缺乏是普遍存在的,并影响各种生理功能.
- 夜间下泌尿道症状显著影响生活质量.
研究的目的:
- 系统地审查和元分析维生素D状态或摄入量与nLUTS之间的关联.
- 为了澄清维生素D在nLUTS病变发生中的作用.
- 评估维生素D补充剂对nLUTS的潜在治疗效果.
主要方法:
- 在PubMed,Scopus,Embase和Web of Science数据库中进行全面搜索,截至2025年7月.
- 包括病例控制,横截面,队列研究和随机对照试验 (RCT).
- 从17项研究 (5项RCT,2个队列,4个横截面,6个病例控制) 的数据进行元分析,涉及2725篇文章.
主要成果:
- 维生素D缺乏 (<20 ng/mL) 与nLUTS的概率增加了4.86倍.
- 患有nLUTS的个体平均血清25-基维生素D水平低于7.75 ng/mL.
- 维生素D补充剂减少了86%的nLUTS,并减少了0.23/night的夜间空洞,在儿童群体和夜间多尿症患者中效果更强.
结论:
- 维生素D缺乏是nLUTS的重要危险因素.
- 补充维生素D证明了对管理nLUTS的治疗潜力.
- 评估维生素D状态可以为nLUTS的临床管理策略提供信息.
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