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相关概念视频

Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

5.2K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
5.2K
Phagocytosis00:41

Phagocytosis

92.5K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
92.5K
Phagocytosis00:41

Phagocytosis

7.6K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
7.6K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

8.7K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.7K
Autophagy01:27

Autophagy

5.6K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.6K
Peroxisomes01:24

Peroxisomes

19.9K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
19.9K

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相关实验视频

Updated: Jan 7, 2026

Monitoring Stub1-Mediated Pexophagy
08:26

Monitoring Stub1-Mediated Pexophagy

Published on: May 12, 2023

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佩克索法基与生理学相遇

Michael J Clague1

  • 1Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Liverpool, UK.

The Journal of cell biology
|December 31, 2025
PubMed
概括
此摘要是机器生成的。

新的小鼠模型允许科学家绘制超氧体 (细胞器官) 周转率和pexophagy (其降解) 的地图. 这揭示了细胞特异性差异,并有助于研究新陈代谢和疾病.

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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy

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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

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相关实验视频

Last Updated: Jan 7, 2026

Monitoring Stub1-Mediated Pexophagy
08:26

Monitoring Stub1-Mediated Pexophagy

Published on: May 12, 2023

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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
06:15

Quantification of Efferocytosis by Single-cell Fluorescence Microscopy

Published on: August 18, 2018

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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

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科学领域:

  • 细胞生物学 细胞生物学
  • 代谢过程中的代谢.
  • 生物化学 生物化学

背景情况:

  • 过氧体是参与各种代谢过程的重要器官.
  • 了解过氧体的动态和循环对于细胞健康至关重要.
  • 佩克索法基,即氧体的选择性降解,是关键的质量控制机制.

研究的目的:

  • 开发新的小鼠模型,以组织分辨率绘制Peroxisome周转和pexophagy.
  • 研究食在发育,新陈代谢和疾病中的作用.
  • 探索食与线粒体质量控制和代谢平衡的整合.

主要方法:

  • 创新小鼠模型的生成和利用.
  • 对过氧酶体动态的组织特异分析.
  • 评估不同生理条件的食率.

主要成果:

  • 证明成功地通过组织解析绘制过氧体周转和食的图谱.
  • 鉴定出过氧酶体动态中细胞类型特异性的显著差异.
  • 建立了一个多功能平台来研究pexophagy.

结论:

  • 开发的小鼠模型为Peroxisome生物学提供了前所未有的洞察力.
  • 佩克索法基在各种细胞类型和条件中表现出不同的模式.
  • 这项研究提供了一个新的工具来研究食,线粒体健康和代谢调节之间的相互作用.