诱导性T细胞共刺激剂 (ICOS) 和ICOS配体:应对双面癌症免疫调节系统
Mina Nikanjam1, Shumei Kato1, Daisuke Nishizaki1
1Division of Hematology-Oncology, University of California San Diego, La Jolla, California, USA.
Cancer medicine
|December 31, 2025
概括
诱导性T细胞共刺激器 (ICOS) 和其连接体 (ICOSL) 途径影响免疫反应. 针对ICOS的治疗方法显示出希望,特别是针对个性化癌症治疗的生物标志物驱动方法.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 诱导性T细胞共刺激器 (ICOS) 和ICOS连接体 (ICOSL) 途径在免疫刺激和抑制中起着双重作用.
- 在不同癌症类型中,ICOS和ICOSL的表达是异质的.
研究的目的:
- 审查ICOS和ICOSL的行动机制.
- 总结它们在癌症和其他疾病中的表达模式.
- 概述研究ICOS向治疗的临床试验.
主要方法:
- 对ICOS和ICOSL的文献综述.
- 分析各种疾病中的表达模式.
- 针对ICOS向剂的正在进行和已完成的临床试验的摘要.
主要成果:
- 由于该途径的双向免疫效应,ICOS激动剂和抗剂都处于临床开发阶段.
- ICOS激动剂在恶性瘤中表现出有限的疗效,可能是由于缺乏基于生物标志物的试验.
- 一种ICOS对抗剂在血管免疫发育T细胞淋巴瘤中显示出44%的响应率,其中ICOS在T-状辅助细胞上表达很高.
结论:
- 基于生物标志物的策略对于个性化ICOS向组合疗法至关重要.
- 确定哪些癌症患者从ICOS导向治疗中获益最多是必不可少的.
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