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Updated: Jan 7, 2026

Analysis of SCAP N-glycosylation and Trafficking in Human Cells
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在Scap上的跨膜螺旋和膜胆固醇之间的竞争调节了Scap-Insig相互作用和SREBP激活

Blake C Williams1, Daniel L Kober2, Xiao-Chen Bai1

  • 1Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Proceedings of the National Academy of Sciences of the United States of America
|December 31, 2025
PubMed
概括

细胞内膜网中的Scap和Insig蛋白质对胆固醇的感知对于细胞脂质平衡至关重要. 一个新的冷EM结构揭示了胆固醇与Scap/Insig结合如何调节SREBP活动,影响胆固醇合成.

关键词:
对于SREBP来说,这是一个很好的选择.这就是Scap Scap.胆固醇 胆固醇 胆固醇 是一种脂质新陈代谢 脂质新陈代谢

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