沙特阿拉伯的困难杆菌感染:在第三级医院环境中的患病率,危险因素和结果
Abdullah M Aldhaif1, Mohammed A Al-Garni1, Ahmed A Muyidi2
1Molecular and Medical Microbiology Laboratory, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
PloS one
|December 31, 2025
概括
困难菌感染 (CDI) 影响了沙特阿拉伯10.8%的住院患者,复发率为11.4%. 抑制酸的使用和组合疗法是重复的关键预测因素,突出需要改进管理和遵循指南的治疗方法.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 临床微生物学 临床微生物学
背景情况:
- 困难菌感染 (CDI) 是一个重要的医疗相关感染.
- 沙特阿拉伯CDI的当代数据有限.
- 这项研究解决了对该地区CDI的最新流行病学和临床见解的需求.
研究的目的:
- 为了确定沙特第三级教学医院住院患者中CDI的患病率.
- 为了确定与CDI收购相关的风险因素.
- 调查CDI复发的预测因素,并分析当前的治疗模式.
主要方法:
- 对2023年3月至2024年2月期间查的1,054名住院患者进行了回顾性分析.
- 使用毒素测定和/或核酸放大测试 (NAAT) 确认了CDI诊断.
- 关于人口统计,临床因素,抗生素使用,抑制酸的使用和治疗的数据采集并使用后勤回归来分析.
主要成果:
- 总体CDI患病率为10.8% (114/1,054),患者中位数年龄为37岁,32.5%患有恶性瘤.
- 接触抗生素 (美罗烯姆, ceftriaxone) 和使用抑制酸的药物 (omeprazole) 是常见的先前因素.
- 在多变量分析中,在11.4%的病例中观察到复发,与抑制酸的使用和组合治疗 (美特罗尼达加万科米辛) 有显著的关联.
结论:
- 在这个沙特第三级医院队列中,CDI的患病率相当高,为10.8%,复发率高达11.4%.
- 酸抑制剂暴露和组合疗法成为复发的显著预测因素.
- 人们过度依赖甲化单一治疗,需要加强抗生素和抑制酸的管理,并遵守国际CDI管理指南.
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