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检测骨转移的Al18F-NOTA-HER2-BCH与18F-FDG PET/CT:灵敏度和定量比较

Xiaoyi Guo¹, Jiayue Liu¹, Huan Ma¹

¹Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine.

Clinical nuclear medicine

|December 31, 2025

概括

与18F-FDG PET/CT相比,Al18F-NOTA-HER2-BCH PET/CT在HER2阳性乳腺癌中显示出优异的骨转移检测. 这种新型药物对于检测小病变和早期病变特别有效.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
放射学放射学是一门学科.

背景情况:

HER2阳性乳腺癌经常转移到骨.
准确检测骨转移对于治疗计划和预后至关重要.
18F-FDG PET/CT是一种标准的成像方式,但其对骨转移的敏感性可能有限.

研究的目的:

为了比较Al18F-NOTA-HER2-BCH PET/CT和18F-FDG PET/CT的诊断性能.
评估HER2阳性乳腺癌患者骨和内脏转移的检测率.

主要方法:

64名HER2阳性乳腺癌患者的回顾性分析.
对18F-NOTA-HER2-BCH PET/CT和18F-FDG PET/CT成像进行比较.
由两个独立的读者进行损伤评估,用SUVmax和TBR量化吸收.

主要成果:

与18F-FDG PET/CT (87.0%和93.8%) 相比,Al18F-NOTA-HER2-BCH PET/CT对骨转移具有更高的敏感性 (100.0%) 和准确性 (96.9%).
通过Al18F-NOTA-HER2-BCH实现了骨质质,骨解质和CT隐形骨损伤的完整检测.
Al18F-NOTA-HER2-BCH检测到显著更多的亚厘米骨转移,并显示了早期内脏转移识别的潜力.

结论:

Al18F-NOTA-HER2-BCH PET/CT提供了在HER2阳性乳腺癌中优异的骨转移的检测.
这种药物对于识别早期,CT隐形和小骨损伤特别有价值.
Al18F-NOTA-HER2-BCH PET/CT可能会改善同时发生的内脏转移的检测.

关键词:

聚乙烯/聚乙烯/聚乙烯骨转移发生在骨中.乳腺癌乳腺癌乳腺癌同时发生内脏转移.

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