暴露于重金属,双A和酸盐:对早熟或延迟的青春期的影响
Seung-Ah Choe1,2, Eunjung Kim3, Mina Ha3
1Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
PloS one
|December 31, 2025
概括
环境化学物质暴露,包括双A (BPA) 和酸盐,与青春期计时障碍有关. 这项研究发现了这些暴露与儿童和青少年早发或延迟青春期之间的关联.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 青春期的时间对儿童的发展至关重要.
- 环境化学物质如重金属,双A (BPA) 和酸盐无处不在.
- 青春期时间的干扰可能会对长期健康产生潜在的后果.
研究的目的:
- 调查暴露于重金属,BPA和酸盐与早发性或延迟性青春期风险之间的联系.
- 分析对这些化学品的单次和混合暴露.
主要方法:
- 使用韩国环境暴露和健康调查数据进行的横截面研究.
- 测量血液中的,,以及尿中的BPA和酸盐代谢产物.
- 使用坦纳阶段评估性成熟.
- 使用后勤回归和量子g计算混合模型进行统计分析.
主要成果:
- 在1,424名参与者中,早期青春期观察到3.5%,延迟青春期观察到3.8%.
- 较高的单乙酸盐水平与女孩的青春期延迟有关.
- 对BPA和甲酸盐的混合暴露显示了与男孩早发性和男孩晚发性之间的关联,尽管不准确.
结论:
- 暴露于环境化学物质,特别是BPA和酸盐,可能会导致改变青春期的时间.
- 需要进一步的研究来澄清与化学混合物相关的确切风险.
- 研究结果强调了环境暴露对发育期间内分泌干扰的潜在影响.
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