长期COVID患者中病毒感染后行为特征:对Fitbit数据和患者报告结果的前性,观察性,纵向性队列分析
Tianmai M Zhang1,2, Sydney P Sharp1, John D Scott3
1Laura Rodriguez Research Institute, Family Health Centers of San Diego, San Diego, CA, United States.
长期COVID患者可以保持适度至剧烈的体力活动 (MVPA),尽管有症状. 客观的可穿戴数据揭示了影响患者报告结果的独特活动概况,指导个性化的长期COVID治疗.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 康复医学 康复医学 康复医学
背景情况:
- 长期COVID呈现出令人衰弱的症状,客观数据有限,将行为和生理学与患者体验联系起来.
- 以前的研究通常依赖于主观的自我报告,需要客观的措施来全面了解长期COVID.
研究的目的:
- 用可穿戴设备对长期COVID患者的身体活动,生理学和患者报告结果 (PRO) 进行纵向分析.
- 根据活动模式和它们与PROs的相关性,在长期COVID队列中识别不同的患者子组 (表型).
主要方法:
- 一项前性,观察性,纵向队列研究,涉及172名长期COVID患者使用Fitbit设备进行持续监测.
- 患者在基线,3个月和6个月完成了验证的问卷 (PROMIS-29,症状调查).
- 分析使用线性混合效应回归比较中度至剧烈体力活动 (MVPA) 活跃和不活跃组.
主要成果:
- 与MVPA活性患者相比,MVPA活性患者在基线报告的身体功能,疲劳和呼吸障碍明显恶化.
- 长度数据显示,MVPA无活跃患者的社会角色参与度下降,睡眠症状强度随着时间的推移而增加.
- 客观的可穿戴数据提供了关于长期COVID中身体活动水平和症状严重程度之间的关系的见解.
结论:
- 长期COVID患者可以参与MVPA,挑战关于普遍活动限制的假设.
- 客观测量的个体活动概况对于制定有效的长期COVID治疗计划至关重要,特别是在低收入人群中.
- 结果产生了假设,强调了鉴于研究的探索性和局限性,需要进一步研究.
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